Erica Rex
Scientific American
06/24/2010

The first discovery of a cancer gene marker—the BRAF oncogene for melanoma and colorectal malignancies—back in 2002 changed the way many researchers thought about cancer treatment. Rather than approach the disease based on what region of the body it stemmed from, scientists began to identify cancers in terms of their genetic signatures. Researchers now recognize more than 200 kinds of cancer—all genetically unique.

And pinpointing a genetic signature, such as EGFR mutations in lung cancer or HER2 mutations in breast cancer, can guide therapy decisions. Narrowing the treatment to a particular tumor cell type makes for a more effective—and less harmful—oncolytic approach. But a new class of cancer therapy is going even further by combining targeted treatments with personalized immune therapy.

The first of these therapies to be approved by the U.S. Food and Drug Administration, Provenge, hit the U.S. market in April, delivering a personalized punch to patients’ prostate tumors. Provenge, and other immunologically based treatments under development do not prevent disease the way the HPV (human papillomavirus) vaccine staves off cervical cancer by using a weakened or dead virus. Instead, the vaccines use killed autologous tumor cells from the patient to activate the immune system.

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New Scientist
06/02/2010

PREVENTION is the goal of most vaccines. Not so vaccines against cancer, which rally the immune system to fight an existing disease. That approach might change now that a protein has been found that stops mice developing breast cancer.

Vincent Tuohy of the Cleveland Clinic in Ohio and colleagues took a protein made by cancerous, breast cells, and injected it into mice engineered to develop breast cancer. This primed their immune systems to attack tumour cells and prevented cancer (Nature Medicine, DOI: 10.1038/nm.2161). As the protein is made by healthy lactating cells, too, such a vaccine might one day prevent cancer in non-lactating women.

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Interview with Edward Haslam – Runtime 57:52

Love Affair – 1/5

Love Affair – 2/5

Love Affair – 3/5

Love Affair – 4/5

Love Affair – 5/5

Get the book that discusses the contamination of the polio vaccine and the Medical Manhattan Project that used radiation to mutate monkey viruses in hopes of developing an anti-cancer vaccine. Hear him describe what is wrong with the official explanation of Dr. Mary Sherman’s murder. And hear him introduce his new witness, Judyth Vary Baker, who has come forward to explain how she became involved in the underground medical laboratory in David Ferrie’s apartment… and how Lee Harvey Oswald was involved.